Stem cells in hematopoietics
Introduction
Hematopoietic stem cells that appear first in the embryo are characterized by being pluripotential, since they are the precursors of the different types of cells in the blood and have a large proliferative capacity because they are able to divide. They are also called hemocytoblasts, and are responsible for producing a large number of progenitor cells in the following stage of differentiation that are more specialized.
They also produce a smaller number of cells of the same type (pluripotential) to have a reserve in order to replace different individual lines of cells perpetuating the population so it is said that they are renewable car. These pluripotent stem cells will maintain our core function throughout our lives.
Developing
In the early embryonic phase, the line of cells that form the blood is subdivided into two different lineages. The first is the lymphoid stem cells that are going to produce the two lines of lymphocytes that are, the T lymphocytes and the B lymphocytes, the former will be in charge of producing antibodies and the latter related to the production of antibody.
The second lineage corresponds to myeloid stem cells that are the precursors of, erythrocytes, platelets, monocytes and granulocytes in what neutrophils, basophils and eosinophils are found. As mentioned above, stem cells belonging to the second generation (lymphoid cells and myeloid cells) continue.
Hematopoietic stem cells are usually called colon -forming units (CFU) due to the behavior they present in certain experimental situations. First generation stem cells are those that will give rise to the two different types of cell lineages that are lymphoid and myeloids so they will know them as CFU-ML.
The stem cells of the second generation will be called CFU-L (lymphocytes) and CFU-S (spleen), these are stem cells responsible for giving rise to only one type of mature blood cell. The different cell types that will form each lineage to go through several differentiation processes until they reach its full maturation.
For the differentiation of stem cells to specific cell lineages, controlling factors will be needed. The existence of colonies stimulating factors (CSF) that are diffusible proteins that will stimulate the proliferation of hematopoietic stem cells have been demonstrated through experiments, these factors will act in various cell types like others in just a cell rate.
conclusion
It has been determined that many of them are produced by bone marrow stroma cells and in other cases they can be stored in the local extracellular matrix. Likewise, Hox genes, especially Hoxa and Hoxb families, have an important role in certain aspects of hematopoiesis. The bone marrow when exposed to antisntid oligonucleotides against specific Hox genes will produce the suppression of certain concrete lines of differentiation of blood cells.
Hox genes will have a very important function in hematopoiesis that will be the regulation of proliferation. Several growth factors, in essential Indian.
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