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Research problem(s). The research problem was to ascertain the biological factors that underpin the sex differences in sensitivity to opioid antagonists. Many studies have examined how genetic discrepancies may result to sensitivity to opioid receptor antagonist. However, no study has examined and described the biological factors that engender such effects. Research Question(s) or Hypothesis The study had two research questions. The first one was to examine the effect of MC phase on acute cortisol, LH, prolactin, and subjective responses prone to naltrexone among women. The second question sought to find out the comparisons between womens’ and mens’ responses to naltrexone. The hypothesis of the study was that women possess a higher tone of an opioid during the luteal phase of MC as opposed to early follicular phase in women and men. This implies that the sensitivity to naltrexone dose would be acute, with more subjective and hormonal responses. Significance of the Study The study is important because it highlights significant implications for naltrexone use in women. For instance, the findings revealed that women in luteal phase are more sensitive to acute subjective and hormonal effects of naltrexone compared to men and women in early follicular. Methods and procedure The study used psychiatric interview for diagnosis, completion of a range of questionnaires, and general physical examination conducted by the study nurse. The questionnaires included the State-Trait Anxiety Inventory, the Beck Depression Inventory, and the Childhood Trauma Questionnaire. Evaluation of the Methods and Procedures The methods and procedures were important because they allowed the study
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