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Outline proposal of Amphetamine An Evaluation of Euphoric Property of Amphetamines Introduction: Definition, Classification, and Features of Amphetamines (Heal et al., 2013). How euphoria is related to addiction. This paper will focus on amphetamine addiction and the implications of amphetamine addiction in enhancing performance. This paper will emphasize the structure-function relationship of amphetamine in producing addiction and euphoria. History and Background of Amphetamines General information on the euphoric potential of amphetamines (Heal et al., 2013, Glennon, 2013). Natural and Commercial Sources of Amphetamines. Chemistry and Pharmacokinetic/Pharmacodynamic (PK/PD) properties of Amphetamines. (Should include ADME: Absorption, Distribution, Metabolism, and Excretion). Bioavailability and elimination half-life to be stated (Heal et al., 2013). History (discovery of amphetamines, identification of the potential for addiction and substance abuse agent) (Heal et al., 2013). Epidemiology of Amphetamine use Need for Euphoria: Special focus on Amphetamines as a doping agent in competitive sports. Literature/evidence of performance enhancement potential of amphetamines. Pathogenesis of Euphoria The role of Amphetamines in stimulating Ventral tegmentum and Nucleus Accumbens to release dopamine (Spencer, Devilbiss & Berridge, 2015) The impact of Amphetamine-Amphetamine receptor interaction on the reward-punishment pathway of our brain. How amphetamine functions as dopamine agonist or potentiates the action of dopamine? ( Synergism and antagonism to be discussed) The role of amphetamines on dopamine receptors? Is there any cross-talk between
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