Aspirin And Its Adverse Effects

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Aspirin and its adverse effects

Summary

This drug is a very popular NSAID that is used daily in the treatment for pain and inflammation of multiple tissues, in addition to multiple studies, they report that it has a property that makes the platelets responsible for blood coagulation lose their effects on the circulatory level. Because of this, several health professionals recommend acetylsalicylic acid to prevent diseases of blood and myocardial vessels. Today it has been discovered in studies with more than twenty thousand patients that its administration will be counterproductive every day instead of beneficial by producing effects as toxic in the stomach, the index of side effects of this is very high in patient in the patient of the patient of the Hemodialysis area.

Keywords: aspirin, efficacy, adverse events.

Introduction

This NSAID is known in the world as aspirin just as ibuprofen is the most effective anti -inflammatory at the national level, serious, serious operatories is used in bone disease of several investigations its great efficacy was reported as an antiplatelet (Magbri, 2014).

Its clinical use in the area of ​​health is several years ago it was achieved in plants that contained these pharmaceutical properties and chemical derivatives its uses of this plants were recognized, which were very famous for their pharmacological effects characteristic of NSAIDs. It was discovered that it produced stomach diseases, the current aspirin is the artificial product obtained from these plants and excipients were added to improve tolerance and reduce a percentage of adverse effects (Loke, 2010).

In the world it is currently known that this drug has in addition to the aforementioned pharmacological characteristics also functions as an antithrombotic and acts on the place of action of different oxygenates that are necessary to produce other enzymes in charge of coagulation together with platelets by That is recommended dose of about sixty to 80 milligrams to use as an inhibitor and cardiovascular diseases but in higher doses it is used because it would inhibit other enzymes which will produce a healing action in migraines, inflammations, high temperature (Joann G Elmore, 2019 ).

In cases of women in a state of gestation, this drug has been used for prevention of prevention because they will present retention of liquids and edema especially to prevent the accumulation of clot. (Liona Poon, 2017)

Developing

Acetylsalicylic acid is a drug used in the elderly to relieve discomfort, serious pain, migraines, bone pain inflammation of muscles, fevers in children, heart disease to control preclassia in patients that dialysis is performed to prevent it from being Coagule blood when purifying its multiple uses have been notified in patient with bone system diseases such as osteoporosis, gout and different types of osteoarthritis because it helps patients to minor their pains (Jennifer B. Dressman, 2012).

A report made to thousands of patients verifies the effectiveness of this product as an antiplatelet that is why it recommends it worldwide for people who must perform dialysis. Its administration is optimal together with heparins to improve the patient’s quality of life with effectiveness. to prevent a very high percentage of heart attacks in the elderly who have high glycemia and blood pressure that are more likely to suffer them (Szczeklik, 2006).

The action of this acid lies in reducing the action of blood proteins in order to avoid the possible formation of some type of thrombus producing the tapping of blood vessels and some kind of infarction producing death. It is used by managing it in a heparin therapy and sodium bicarbonate in different doses depending on the patient’s case, the values ​​help us verify that the objective as an antiplatelet drug is optimal and the side effects are minimal this will vary according to the idiosyncrasy of the individual but more than fifty percent to stable values ​​verifying their reliability (ENMA V. Paez Espinosa, 2012).

In clinical trials, not all medicines pass the tests performed, so there is a small number of people where aspirin has not obtained the expected results but compared to other medications its range is high in large populations that have used it but should always be used With combined doses as prescribed the doctor because it can produce stomach pain and it is highly hepatotoxic and resistance to this analgesic can be developed and its effect would not be adequate, therefore it would be recommended to use a greater dose due to the loss of the therapeutic effect such as helping in heart problems .The latest studies that were carried out are based on an analysis of acetylsalicylic acid to prevent its adverse effects (Szczeklik, 2006).

Schizophrenia is a pathology of the mind that is related to a process of alteration in neurotransmitters located in the brain area and an inflammation of this. The salicyls when characterized by their function of deflament are also used for this type of diseases, which has turned out very well because people with this mental problem have demonstrated a decrease in migraines characteristic of this disease. Psychiatrists have lately opted for Medicine with aspirin compared to other medications because they reveal less effects at the gastric level (Lena Schmidt, 2019).

Scientists plan to perform more rehearsals to verify this amazing benefit found in aspirin because it could infinitely help patients not only with schizophrenia problems but in patients who present mental disorders such as bipolarity but more scientific evidence is still needed because in the long term It would produce a counterproductive effect (Karen Estefanía Hernández Moreno, 2017).

Using this drug as a blying of psychotropics is a possibility that could immeasurely help individuals especially comparing the monetary value of acetylsalicylic acid (Shokraneh, 2019).

conclusion

It can be concluded that the adverse effects of aspirin are minimal if we compare them with all the benefits that it provides us with in addition to having all the characteristic pharmacological properties of NSAIDs is also useful in patients with cardiovascular diseases, with preclassia and arthritis. The adverse effects are very few but an exhaustive control by the treating doctor is recommended.

Bibliography

1. Enma v. Paez Espinosa, J. P. (July 3, 2012). Aspirin: Pharmacology and Clinical Applications. Hindawi Publishing Corporation, 1-15. DOI: 10.1155/2012/173124
2. Jennifer b. Dressman, a. N. (August 12, 2012). Biowaiver Monograph for Immediate-Release Solid Oral Dosage. Journal of Pharmaceutical Sciences, 101 (8). DOI: 10.1002/JPS.23212
3. Joann G Elmore, M. M. (April 12, 2019). Aspirin in the Primary Prevention of Cardiovascular Disease and Cancer. Scielo. Retrieved on August 17, 2019, from https: // www.Uptodate.com/Contents/Aspiin-in-The-Primary-Prevention-Of-Cardiovascular-Disease-And-Cancer?SEARCH = acetylsalicylic%20acid & source = search_result & selected = 2 ~ 150 & usage_type = default & dispay_rank = 2
4. Karen Estefanía Hernández Moreno, R. C. (03 of 11 of 2017). Aspiin-Exacerbated Respiratory Disease. Case-Based Review Respiratory disease exacerbated by aspirin. Review from clinical cases. Rev allerg Mex, 78-91. Retrieved on 08 of 2019, from http: // www.Scielo.org.MX/PDF/RAM/V65N1/2448-9190-RAM-65-01-78.PDF
5. Lena Schmidt, and. P. (August 10, 2019). Acetylsalicylic acid (aspirin) for schizophrenia. DOI: 10.1002 /14651858.CD012116.Pub2
6. Liona c. Poon, m. D. (November 12, 2017). Aspirin for evidence-base preeclampsia prevention trial: Effect of aspiin in prevention of preterm preeclampsia in subgroups of women according to their characteristics and medical and obstetric history. Original Research Obstetrics, 1-5. Retrieved on 08 of 2019, from https: // www.AJOG.ORG/ARTICLE/S0002-9378 (17) 30929-8/PDF
7. Loke, c. S. (May 15, 2010). Critical Overview On The Benefits and Harms of Aspiin. Pharmaceuticals, 1491-1506. DOI :: 10.3390/pH3051491
8. Magbri, m. (February 12, 2014). The Synthesis and Analysis of aspirin. Journal Chemical Education. Retrieved on August 17, 2019, from https: // pdfs.Semanticscholar.Org/5E9A/F12EECB0D610768B5C45B4F249CAB0FBE630.PDF
9. Peter M Rothwell, N. R. (July 12, 2018). Effects of aspirin on risks of vascular Events and Cancer According to Bodyweight and Dose: Analysis of Individual Patient Data From Randomized Trials. Center for Prevention of Stroke and Dementia, 361. DOI: 10.1016/
10. Szczeklik, a. (2006). The History of Aspirin: The Discoveries That Changed Contemporary Medicine. Paths of Discovery, 175-182.